Peripheral Arterial Disease – Unmet Need – Detailed, Expanded Analysis (US & EU)

Market Outlook

Peripheral arterial disease (PAD) is a complex manifestation of underlying atherosclerotic disease and is severely undertreated. The failure of therapies to improve walking distance or reduce amputation highlights the need for novel agents capable of reducing, preventing, or reversing the progression of PAD. We discuss how current therapies are differentiated based on their key attributes and measure the impact of these attributes on cardiologists’ prescribing behavior. We also discuss the most important unmet needs in the treatment of PAD and consider which emerging therapies, if any, can capitalize on these opportunities. Our conjoint analysis reveals the key trade-offs that surveyed physicians are willing to make for these attributes when considering new treatment options for PAD.


  • Which drug attributes are key influencers, which have limited impact, and which are hidden opportunities?
  • Which PAD therapies are perceived by U.S. and European cardiologists as performing best on key treatment drivers and goals?
  • What are the major areas of opportunity for drug developers in PAD treatment and their likelihood of being fulfilled in the near future?
  • Based on the conjoint analysis and TPP simulation, what trade-offs across different clinical attributes and price are acceptable to U.S. and European cardiologists for a hypothetical new PAD drug?

Markets covered: United States, United Kingdom, France, Germany

Primary research: Survey of 60 U.S. and 30 European cardiologists fielded in June 2019.

Key drugs covered: Aspirin, clopidogrel, statins, Xarelto, Repatha, Praluent, and vasoactive agents.

Key metrics included Target Product Profile (TPP) simulator based on conjoint analysis methodology. Stated versus derived importance of product attributes on prescribing behavior. Assessment of current drug performance against treatment drivers and goals. Physician perceptions of unmet needs in the indication and related indications. Analysis of remaining drug development opportunities.


Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. Two market scenarios are profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.

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