De-risk your R&D programs

Monitor and anticipate toxicology and safety signals, mitigate safety liabilities and de-risk assets across all phases of drug R&D and post-marketing.

Make confident development and investment decisions with comprehensive translational safety intelligence. OFF-X™ provides integrated preclinical toxicity data, clinical and pharmacovigilance adverse event data, visualizations and preclinical safety analytics.

Food and Drug Administration (FDA) and Clarivate Extend Material Transfer Agreement for Three Additional Years

How we help

Benchmark safety profiles and assess risks
Quickly understand safety liabilities of drug classes by comparing the safety profiles of your competitor’s drugs based on daily updated, manually curated data.
Predict preclinical toxicity and anticipate adverse events
Connect and integrate critical safety intelligence from early target discovery to post-marketing and patient safety to anticipate and translate toxicity and safety events derived in the lab to the clinic.
Support signal detection, prioritization, and evaluation
Reduce the time and resources required to retrieve safety intelligence needed to stay abreast of regulatory and pharmacovigilance concerns for a given drug or drug class.

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Why choose us

Comprehensive range of safety information sources and dataset

2.1M+ curated safety and toxicity alerts
15K+ targets and genes
32K+ drugs and biologics
12K+ adverse events and toxicity endpoints
All sourced from peer-reviewed journals, congresses, company communications, clinical trial registries, regulatory agency communications around the world and FDA, EMA, and PDMA approval packages”

User-friendly dashboards

Quickly assess critical preclinical toxicity data and preclinical safety data with user-friendly visualizations and dashboards, including:

Translatability dashboard to anticipate and track potential liabilities as clinical trials starts and actions to mitigate risks
Mechanistic safety dashboard to discover potential mechanisms behind unexpected adverse events
Chemistry dashboard to correlate chemical structures with safety liabilities
Real-world evidence dashboard to quickly assess new potential safety signals

Wide-ranging analytics and visualizations

Support R&D, clinical and pharmacovigilance teams with comprehensive safety data and analytics, including:

Target class score to identify and monitor emerging target class liabilities
Mounting evidence charts to assess the safety evidence and trends for a given drug or target-adverse event association
Drug score to estimate the strength of evidence supporting a given drug-adverse event association
Safety maps to assess and prioritize investigational target safety based on human protein interactome data

Integrate internal data and OFF-X via APIs or data feeds

Connect to translational safety data ecosystem through APIs or data feeds
Integrate with in-house data sources and modeling applications
Enrich and expand depth of internal resources to enable your teams to uncover hidden insights in data