DRG estimates that 60% of epilepsy patients experience partial-onset seizures (POS). More than two dozen antiepileptic drugs (AEDs) are available in the United States and Europe—the majority of which are approved to treat POS—yet 20-30% of all epilepsy patients are refractory to AED treatment. While the treatment algorithm in early lines of therapy is generally well understood, later-line prescribing for refractory POS is highly variable, in part because seizures in epilepsy are diverse and newer therapies lack clear clinical differentiation. As such, treatment choice is often based on neurologists’ personal experience. Understanding the drivers of clinical decision-making for treating refractory POS and prescriber perceptions of third-generation brands will help innovators identify levers for new product positioning and differentiation in this crowded yet underserved market.
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Product Description
Unmet Need: Provides quantitative insight into U.S. and European physician perceptions of key treatment drivers and goals and the current level of unmet need for a specific disease. Commercial opportunities are analyzed, and the extent to which emerging therapies may capitalize on these opportunities is evaluated.
Markets covered: United States, United Kingdom, France, and Germany.
Primary research: Survey of 61 neurologists in United States and 30 neurologists in Europe.
Key companies: Sunovion Pharmaceuticals, Eisai, UCB, Pfizer, Janssen, and Concordia Pharmaceuticals.
Key drugs: Aptiom/Zebinix, Briviact, Fycompa, Lyrica, topiramate, Vimpat, and zonisamide.
Key metrics included: