MARKET OUTLOOK
The accelerated approvals of Kymriah (Novartis) for the treatment of children and young adults with relapsed/refractory B-cell acute lymphoblastic leukemia (ALL) and Yescarta (Kite Pharma, a Gilead company) for relapsed/refractory large B-cell lymphoma herald a new era in cancer immunotherapy. In this series of reports, we present a comprehensive analysis of current and emerging chimeric antigen receptor (CAR) T-cell therapies. We examine the CAR T-cell treatment landscape: the technology behind it, ongoing clinical development, the challenges, pricing and market access, physicians’ views, and future opportunities for this paradigm-shifting treatment approach.
QUESTIONS ANSWERED
- How is CAR T-cell therapy being adopted into medical practice? What kind of referral patterns are in place for potentially eligible patients? What is the typical patient journey for a patient receiving CAR T-cell therapy?
- What kind of support and training programs for Kymriah and Yescarta are in place for healthcare professionals, patients, and caregivers?
- What are the key pricing, access, and reimbursement issues facing Kymriah and Yescarta? What novel reimbursement strategies are marketers implementing to ensure market access?
- What challenges remain and could limit widespread and maximum adoption of autologous CD19-targeted CAR T-cell therapies? What are the future directions and opportunities?
- What are the notable developments in the pipeline? Who are the key players, and what novel targets are they exploring?
PRODUCT DESCRIPTION
Special Topics Report Series: Is a three-wave series based on KOL interviews conducted at about one, six, and twelve months postcommercialization and on secondary data collected from a variety of sources. We capture physicians’ awareness, perception, and use of the launched product and anticipated future trends.
Markets covered: United States
Primary research: Qualitative interviews with ten U.S. hematologist-oncologists and thought leaders for the three waves.
Key metrics included:
- Physician familiarity with and impressions of Kymriah, Yescarta, and other CAR T-cell therapies in the pipeline.
- Referral patterns, patient journey, and certification of treatment centers.
- Current manufacturing and scalability challenges.
- Marketing and educational programs for patients, healthcare professionals, and caregivers.
- Cost of CAR T-cell therapy and novel pricing and market access strategies.
Anamika Ghosh, Ph.D.
Anamika Ghosh, M.Sc., Ph.D., is a manager on the Oncology team at Clarivate. She has expertise in various solid and hematological malignancies and immune-oncology drug classes, such as immune checkpoint inhibitors and CAR T-cell therapies. As a Ph.D. and postdoctoral fellow at the International Centre for Genetic Engineering and Biotechnology (ICGEB), Dr. Ghosh studied host-pathogen interactions during Mycobacterium tuberculosis and Dengue virus infections. She received her Ph.D. in life sciences from ICGEB and an M.Sc. in biomedical sciences from the University of Delhi.
Rachel Webster
Rachel Webster, M.Sc., M.A. (Honors), D.Phil., is principal director and head of the Oncology team at Clarivate. She leads the team in the production of syndicated primary and secondary market research reports and custom analysis of a wide range of oncology indications. Dr. Webster also provides client support for all oncology products and helps biopharmaceutical companies uncover strategic opportunities through data-driven insights from a variety of channels. She has more than ten years of experience in market forecasting and a broad knowledge of oncology indications and markets; she has a particular interest and expertise in immuno-oncology. Previously, Dr. Webster was a research scientist at Immunocore in the target validation group. She has published numerous oncology market assessment articles in Nature Reviews Drug Discovery and, in 2017, developed a new DRG oncology product called Treatment Sequencing. She received her doctorate from the University of Oxford.