Retinal Vein Occlusion – Executive Insights – Executive Insights (US)

Retinal vein occlusion (RVO) is a major cause of blindness in the major pharmaceutical markets. Patients are segmented by the anatomic location of the occlusion; thus, they are classified as having branch, central, or hemi-retinal vein occlusion (BRVO, CRVO, HRVO, respectively). Because RVOs compromise venous return from the retinal circulation, they may trigger retinal ischemia, macular edema, and/or neovascularization. The standards of care for macular edema following RVO include the anti-VEGFs Eylea (Regeneron / Bayer), Lucentis (Roche / Genentech), and off-label Avastin (Roche / Genentech) and the corticosteroid implant Ozurdex (AbbVie). Notably, Roche / Chugai expect to submit an expanded application for Vabysmo for BRVO and CRVO in the United States and Europe in 2023. Although the number of therapies in development for RVO is small, commercial opportunity remains for therapies with a longer dosing duration, greater efficacy, and/or a convenient route of administration.


  • What diagnostic tests are used to characterize RVO patients, and how are different patient subtypes treated?
  • What are the physician-perceived advantages and disadvantages of current therapies?
  • What are the key areas of unmet need and opportunity in the RVO market?
  • What are the key strengths, weaknesses, drivers, and constraints of the RVO market?
  • What influence does each major player hold over the RVO market?
  • What are the competitive landscape and the expected future influence of key emerging therapies, including Roche / Chugai’s Vabysmo, in the treatment of RVO?


United States


3 KOL interviews in July 2023


Regeneron, Roche/Genentech, AbbVie (legacy Allergan), Biogen, Coherus, Annexin, 3T Ophthalmics

KEY DRUGS COVERED ANXV, Avastin, Byooviz, Cimerli, Eylea, Eylea HD, Lucentis, Ozurdex, ONS-5010 (Lytenava), RG-7921


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