Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory disorder affecting hair follicles. Humira is the only FDA-approved therapy for the disease; its use is limited—based on the label—to patients with moderate to severe disease. In addition, a variety of therapies (e.g., antibiotics, hormonal agents, retinoids, corticosteroids) are prescribed off-label for HS. Alternative biologics may also be used off-label in patients with more-severe disease who do not respond to Humira (e.g., Janssen’s Stelara). The HS pipeline holds a diverse array of therapies with unique mechanisms of action, such as IL-17 inhibitors (Novartis’s Cosentyx), IL-23 inhibitors (AbbVie’s Skyrizi and Janssen’s Tremfya), IL-1 inhibitors (bermekimab), and JAK-1 inhibitors (INCB054707). If proven efficacious, these agents will enjoy huge commercial opportunity because of the immense unmet need in this space.
United States Primary Research 3 KOL interviews in October 2019
Key COMPANIES Covered
AbbVie, Novartis, Janssen, XBiotech, Incyte
Key Drugs Covered
Humira, Cosentyx, Skyrizi, Tremfya, Remicade, Stelara, metformin, spironolactone, clindamycin, rifampicin, bermekimab, INCB054707
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