Diabetic cardiomyopathy is a chronic, progressive cardiovascular disease occurring in diabetic patients. It is a prevalent condition that often remains undiagnosed in its early stages due to the lack of symptoms and limited disease awareness. As the disease progresses, HF develops, and patients experience burdensome symptoms. No therapies have been approved to treat DbCM; treatment of patients focuses mainly on the optimal management of diabetes and its comorbid conditions with agents from the antidiabetic, antihypertensive, and lipid-modifying drug classes. The primary goal is to keep the underlying conditions in check to prevent the accelerated progression of DbCM. The DbCM pipeline is relatively bare; only one agent, Applied Therapeutics’ AT-001, has the potential to launch in the next 10 years. Nevertheless, SGLT-2 inhibitors, which are well-established antidiabetic drugs and gaining recognition for their beneficial role in treating HF, are likely to be widely used in this patient population. Considering the number of potential drug targets in DbCM, there is significant opportunity for drug developers to advance therapies with novel mechanisms of action.
Three KOL interviews in May /June 2020
KEY COMPANIES COVERED
Applied Therapeutics, AstraZeneca, Boehringer Ingelheim, Eli Lilly