Spasticity is characterized by an increase in muscle tone and is highly prevalent among patients diagnosed with some neurological conditions (e.g., stroke, multiple sclerosis [MS], spinal cord injury [SCI], traumatic brain injury [TBI]). Wide arrays of therapies are available to treat adult spasticity, including oral anti-spasticity drugs, botulinum toxins, cannabinoids, and intrathecal interventions. However, oral drugs that are generically available (i.e., baclofen and tizanidine) are the most prescribed first-line treatments, followed by the more-efficacious invasive botulinum toxin A therapies (AbbVie’s Botox, Ipsen’s Dysport, Merz’s Xeomin) in later lines. Although current therapies are effective in decreasing muscle tone and improving the quality of life, they have multiple shortcomings (e.g., safety concerns). In addition, late-phase pipeline activity for the treatment of adult spasticity is sparse, with many emerging agents lacking a novel mechanism of action. Interviewed neurologists have highlighted areas of unmet need and expressed expectations from an emerging therapy in adult spasticity. Given the extent of disease burden on patients, neurologists are open to adopt treatment options that demonstrate benefits over the current therapies.
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Geographies: United States, EU5, China.
Primary research: 8 interviews with neurologists in February 2022.
Key companies covered: AbbVie, Ipsen Pharma, Merz Therapeutics, Amneal Pharmaceuticals, Jazz Pharmaceuticals, Revance Therapeutics, Bionorica, RVL Pharmaceuticals, Supernus Pharmaceuticals
Key drugs covered: Botox, Dysport, Xeomin, MyoBloc / NeuroBloc, tizanidine, baclofen, Sativex, Ontinua ER, daxibotulinumtoxinA (DAXI), Gablofen, Ozobax, Lioresal Intrathecal, biosimilar of onabotulinumtoxinA