Nonalcoholic steatohepatitis (NASH) has the potential to be a large and lucrative market for pharmacotherapies owing to the lack of approved agents and the disease’s relatively high prevalence. Only off-label medications are available for NASH, a situation that, when combined with the limited awareness of the disease and the challenges in making a diagnosis, translates to low treatment rates. However, new diagnostics and the anticipated launch of the first therapies approved for NASH should have a positive impact on treatment of the disease. Innovative novel therapies, which may include Intercept Pharmaceuticals’ obeticholic acid, Allergan’s cenicriviroc, and Madrigal Pharmaceuticals’ resmetirom, will be able to command high prices, although these agents’ commercial success will likely be determined by how they are adopted into medical practice.
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