Nonalcoholic Steatohepatitis | Current Treatment: Physician Insights | US | 2022

Nonalcoholic steatohepatitis (NASH) has the potential to be a large and lucrative market for pharmacotherapies owing to the lack of approved agents and the disease’s relatively high prevalence. Only off-label medications are available for NASH, a situation that, when combined with the limited awareness of the disease and the challenges in making a diagnosis, translates to low treatment rates. However, new diagnostics and the anticipated launch of the first therapies approved for NASH should have a positive impact on treatment of the disease. Innovative novel therapies, which may include Intercept Pharmaceuticals’ obeticholic acid, Allergan’s cenicriviroc, and Madrigal Pharmaceuticals’ resmetirom, will be able to command high prices, although these agents’ commercial success will likely be determined by how they are adopted into medical practice.


  • What are U.S. specialists’ attitudes toward and perceptions of the diagnosis and treatment of NASH?
  • How are U.S. hepatologists and gastroenterologists treating NASH patients? What off-label medications are being used?
  • What are the drivers and constraints determining prescribing practices for NASH?
  • How could the availability of the first novel branded NASH agents affect the prescribing landscape?
  • What might emerging NASH drug therapies need to demonstrate to convince prescribers to switch from off-label treatments?


  • Geography: United States
  • Primary research survey of 51 U.S. hepatologists and 50 U.S. gastroenterologists
  • Key drugs covered: Pioglitazone, vitamin E, metformin, SGLT-2 inhibitors, GLP-1 receptor agonists, lipid-modifying therapies, RAAS inhibitors, ursodeoxycholic acid
  • Key insights provided:
    • Factors influencing disease management and treatment decisions.
    • Drivers of treatment selection.
    • Physician-reported treatment practices and brand-level patient shares.
    • Rationale for changes in treatment approach.
    • Physician insight on persistency and compliance.


Current Treatment: Physician Insights provides physician insights on treatment dynamics, prescribing behavior, and drivers of brand use so that clients can create specific messaging around these treatment dynamics in order to more effectively increase or defend their market position.

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