Chronic idiopathic constipation (CIC) is a common gastrointestinal disorder that is characterized by difficulty defecating, including hard stools and a sensation of incomplete evacuation or blockage. CIC can also be associated with abdominal pain and bloating that negatively impact patients’ QOL. The key treatment goals for CIC are improving bowel function and overall symptom relief. Once patients have failed OTC agents, such as bulk-forming laxatives (psyllium, methylcellulose) and osmotic therapies (polyethylene glycol, lactulose), they move to prescription drug therapy. The CIC drug market includes two guanylate cyclase-C agonists, Synergy’s Trulance and Allergan / Ironwood’s Linzess, and one bicyclic fatty acid, Mallinckrodt’s Amitiza. Most recently, Takeda’s Motegrity, a 5-HT4-receptor agonist, was approved for CIC.
Longitudinal patient-level claims data analysis
KEY DRUGS COVERED
Amitiza, Linzess, Motegrity, Trulance
KEY ANALYSIS PROVIDED
Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data so that marketers can accurately assess their source of business, benchmark usage against competitors, and quantify areas of opportunity for their marketed or emerging brand.