The treatment of rheumatoid arthritis (RA) typically begins with cost-effective conventional DMARDs (cDMARDs), such as methotrexate or hydroxychloroquine. For patients who fail cDMARD treatment or have an inadequate response, the U.S. market is crowded with efficacious biologics and targeted oral therapies, including blockbuster TNF-alpha inhibitors (e.g., AbbVie’s Humira, Amgen’s Enbrel) and non-TNF-alpha inhibitors, such as Bristol Myers Squibb’s Orencia and Roche’s Actemra and the oral JAK inhibitors Xeljanz (Pfizer), Olumiant (Eli Lilly), and Rinvoq (AbbVie). Indeed, the FDA’s approval of Rinvoq led to increased competition within the JAK inhibitor class and among the non-TNF biologics. However, the recent extension of the FDA’s safety warnings to the entire JAK class will likely impact the overall use of these drugs, leading to increased uptake of other targeted agents.
Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data so that marketers can accurately assess their source of business, benchmark usage against competitors, and quantify areas of opportunity for their marketed or emerging brand.
Markets covered: United States
Key companies: AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Pfizer, Roche, Regeneron, Sanofi, UCB.
Key drugs: Actemra, biosimilar infliximab, Cimzia, Enbrel, Humira, Kevzara, Olumiant, Orencia, Remicade, Rinvoq, Rituxan, Simponi, Simponi Aria, Xeljanz.
The Treatment Algorithms dashboard is an interactive supplement to our PowerPoint-based claims data analysis reports and retains the full set of analyses included in the reports (i.e., newly diagnosed patients, recently treated patients, persistency, and compliance). The dashboard allows for easier navigation of data visualizations and provides more-detailed analyses examining the flow of treatment regimens in newly diagnosed and recently treated patients.