Although Ofev and Esbriet are welcome options in the treatment armamentarium for idiopathic pulmonary fibrosis (IPF), therapies that can further delay or reverse the disease’s progression, preserve lung function, and prolong survival are sorely needed. The diverse IPF pipeline comprises novel classes including CTGF inhibitors, Rho-associated coiled-coil kinase 2 inhibitors, and agents targeting recombinant human pentraxin-2. In this report, we assess the clinical and commercial opportunities remaining in the IPF space through a comprehensive analysis of surveyed pulmonologists’ treatment drivers and goals and their perception of the performance of key current therapies against these goals.
Markets covered: United States, United Kingdom, France, Germany.
Primary research: Survey of 61 U.S. and 31 European pulmonologists fielded in January 2022.
Key companies: Roche, Boehringer Ingelheim, FibroGen, Promedior / Roche.
Key drugs: Esbriet, Ofev, prednisone.
Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by Clarivate experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.