Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all chronic heart failure (CHF) cases. Our understanding of the pathophysiology of the disease has improved, but pharmacological treatments with proven outcomes benefits in HFpEF have proved elusive thus far. Current clinical guidelines focus on the management of comorbidities with angiotensin-converting enzyme (ACE) inhibitors, beta blockers, and diuretics, but despite the long list of clinical trial failures, promising drugs are in Phase III trials.
QUESTIONS ANSWERED
Markets covered: United States, United Kingdom, France, Germany
Primary research: Survey of 60 U.S. and 30 European cardiologists fielded in August 2019
Key companies: Novartis, Eli Lilly, Boehringer Ingelheim, AstraZeneca
KEY METRICS INCLUDED
Key drugs:ACE inhibitors, angiotensin II receptor blockers,beta blockers, calciumchannel blockers, diuretics, spironolactone, Entresto (sacubitril/valsartan)
PRODUCT DESCRIPTION
Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. Two market scenarios are profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.