Heart Failure – Unmet Need – Detailed, Expanded Analysis Acute Heart Failure (US/EU)
Acute heart failure (AHF) is characterized by the rapid onset or aggravation of symptoms of heart failure. The standard of care in AHF has remained largely unchanged since the 1970s, resulting in a highly genericized market. AHF patients continue to experience high rates of mortality and morbidity because no therapy to date has been able to improve hard clinical outcomes. This study evaluates how current therapies are differentiated based on their performance on key drug attributes and measures the impact of these attributes on the prescribing behavior of cardiologists. Revealing the relative importance of unmet needs helps identify the most attractive opportunities in AHF treatment.
QUESTIONS ANSWERED
- Which drug attributes most strongly influence AHF drug selection?
- How do cardiologists rate key current AHF therapies across select drug attributes?
- Where are the hidden opportunities for drug development in the AHF therapy market?
- Do U.S. and European cardiologists have different perceptions of the unmet need in the treatment of AHF?
PRODUCT DESCRIPTION
Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. One market scenario is profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.
Markets covered: United States, United Kingdom, France, Germany.
Primary research: Survey of 60 U.S. and 32 European cardiologists fielded in December 2019.
Key companies: Novartis, Johnson & Johnson, Pfizer.
Key drugs: Nitrate vasodilators, loop diuretics, inotropic sympathomimetics, PDE3 inhibitors, calcium sensitizers.
Table of contents
- Heart Failure - Unmet Need - Detailed, Expanded Analysis Acute Heart Failure (US/EU)
- Acute Heart Failure Unmet Need TPP Simulator File 2020
- Executive Summary
- Introduction
- Treatment Drivers and Goals
- Key Findings: Attribute Importance
- Relative Importance of Efficacy, Safety and Tolerability, Convenience of Administration, and Nonclinical Attributes to Surveyed Cardiologists' Prescribing Decisions in Acute Heart Failure
- Importance of Efficacy Attributes to Prescribing Decisions in Acute Heart Failure: United States
- Importance of Efficacy Attributes to Prescribing Decisions in Acute Heart Failure: Europe
- Importance of Safety and Tolerability Attributes to Prescribing Decisions in Acute Heart Failure: United States
- Importance of Safety and Tolerability Attributes to Prescribing Decisions in Acute Heart Failure: Europe
- Key Findings: Stated vs. Derived Importance
- Stated vs. Derived Importance of Key Efficacy, Safety and Tolerability, Convenience of Administration, and Nonclinical Attributes to Prescribing Decisions in Acute Heart Failure: United States
- Stated vs. Derived Importance of Key Efficacy, Safety and Tolerability, Convenience of Administration, and Nonclinical Attributes to Prescribing Decisions in Acute Heart Failure: Europe
- Product Performance Against Treatment Drivers and Goals
- Key Findings
- Overall Performance of Key Therapies for Acute Heart Failure: United States
- Overall Performance of Key Therapies for Acute Heart Failure: Europe
- Mean Overall Performance of Key Therapies for Acute Heart Failure: United States and Europe
- Relative Performance of Key Therapies for Acute Heart Failure Across Select Efficacy Attributes: United States
- Relative Performance of Key Therapies for Acute Heart Failure Across Select Efficacy Attributes: Europe
- Relative Performance of Key Therapies for Acute Heart Failure Across Select Safety and Tolerability Attributes: United States
- Relative Performance of Key Therapies for Acute Heart Failure Across Select Safety and Tolerability Attributes: Europe
- Assessment of Unmet Need
- Key Findings: Unmet Need in Acute Heart Failure
- Surveyed Cardiologistsu2019 Satisfaction with the Performance of Key Therapies for Acute Heart Failure on Efficacy, Safety and Tolerability, Convenience of Administration, and Nonclinical Factors: United States
- Surveyed Cardiologistsu2019 Satisfaction with the Performance of Key Therapies for Acute Heart Failure on Efficacy, Safety and Tolerability, Convenience of Administration, and Nonclinical Factors: Europe
- Surveyed Cardiologists' Ascribed Level of Unmet Need Across Key Efficacy Attributes in Acute Heart Failure: United States
- Surveyed Cardiologists' Ascribed Level of Unmet Need Across Key Efficacy Attributes in Acute Heart Failure: Europe
- Surveyed Cardiologists' Ascribed Level of Unmet Need Across Key Safety and Tolerability Attributes in Acute Heart Failure: United States
- Surveyed Cardiologists' Ascribed Level of Unmet Need Across Key Safety and Tolerability Attributes in Acute Heart Failure: Europe
- Key Findings: Unmet Need in Acute Heart Failure and Related Indications
- Surveyed Cardiologists' Ascribed Level of Unmet Need in Acute Heart Failure and Related Indications: United States
- Surveyed Cardiologists' Ascribed Level of Unmet Need in Acute Heart Failure and Related Indications: Europe
- Opportunity Analysis
- Areas of Opportunity in the Acute Heart Failure Market and Emerging Therapy Insights
- Opportunity: A Novel Agent That Significantly Reduces the Rate of Cardiovascular Mortality in Acute Heart Failure
- Opportunity: A Novel Agent That Reduces the Rate of Rehospitalization for Heart Failure
- Opportunity: A Novel Agent That Shows Significant Improvement in the Incidence of Worsening Heart Failure and Reduces the Length of Hospital Stay
- Areas of Opportunity in the Acute Heart Failure Market and Emerging Therapy Insights
- Target Product Profiles
- Appendix
Dwaipayan Chatterjee, M.Pharm., Senior Healthcare Research & Data Analyst, Cardiovascular, Metabolic, Renal, and Hematologic (CMRH) Disorders analyst. Mr. Chatterjee authors reports on metabolic and cardiovascular indications. Previously, he was an equity analyst for the U.S. healthcare sector with Market Realist, where he worked on competitive intelligence and analysis of financial data. He was also a market research analyst for Mordor Intelligence, where he gained experience in market sizing, forecasting, and analyzing market dynamics. He holds a master’s degree with a specialization in pharmaceutical chemistry from the Birla Institute of Technology & Science in Pilani, India.