Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the development and progressive enlargement of fluid-filled cysts in the kidneys. Particularly in the early stages, the disease is often asymptomatic and detectable only through diagnostic imaging of the kidney to reveal cysts. The launch of Otsuka’s Jynarque / Jinarc / Samsca (tolvaptan) introduced the first disease-specific therapy for ADPKD. However, many opportunities remain for emerging ADPKD therapies owing to limitations of tolvaptan. For example, tolvaptan is not a disease-modifying therapy; its efficacy is considered moderate by thought-leaders interviewed; it is indicated only in adults who have rapidly progressing, or are at risk for, rapidly progressing ADPKD; and it is commonly associated with aquaretic adverse events. We examine how tolvaptan’s launch has impacted ADPKD patient treatment and the challenges / opportunities that emerging therapies will face entering this market.
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Special Topic: Quantitative Physician Insights provides physician insights on treatment dynamics, prescribing behavior, and drivers of brand use so that marketers can create specific messaging around these treatment dynamics to more effectively increase or defend their market position.