Retinal vein occlusion (RVO) is a major cause of blindness, and affected approximately 1.6 million patients in 2018 in the United States. Patients are segmented by the anatomic location of the occlusion, and therefore are classified as having branch, central, or hemi-retinal vein occlusion (BRVO, CRVO, HRVO, respectively). Because retinal vein occlusions compromise venous return from the retinal circulation, they may trigger retinal ischemia, macular edema and/or neovascularization. Intravitreally administered biologics targeting vascular endothelial growth factor (anti-VEGF agents; Roche/Genentech’s Avastin, Roche/Genentech’s Lucentis, Regeneron’s Eylea) and corticosteroids (Allergan’s Ozurdex) are used to treat macular edema following RVO. Although the pipeline for emerging RVO therapies is sparse, commercial opportunity exists for therapies with a longer dosing duration, greater efficacy, efficacy in treatment-resistant patients, and that are administered less invasively.
3 KOL interviews in April 2019
KEY COMPANIES COVERED
Regeneron, Roche/Genentech, Allergan, Novartis, Aerie Pharmaceuticals, Cerevast Medical, Taiwan Liposome Company, Kodiak Sciences
KEY DRUGS COVERED Avastin, Eylea, Lucentis, Ozurdex, brolucizumab, AR-1105, TLC399, KSI-301
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