Retinal Vein Occlusion | Executive Insights | US | 2019

Retinal vein occlusion (RVO) is a major cause of blindness, and affected approximately 1.6 million patients in 2018 in the United States. Patients are segmented by the anatomic location of the occlusion, and therefore are classified as having branch, central, or hemi-retinal vein occlusion (BRVO, CRVO, HRVO, respectively). Because retinal vein occlusions compromise venous return from the retinal circulation, they may trigger retinal ischemia, macular edema and/or neovascularization. Intravitreally administered biologics targeting vascular endothelial growth factor (anti-VEGF agents; Roche/Genentech’s Avastin, Roche/Genentech’s Lucentis, Regeneron’s Eylea) and corticosteroids (Allergan’s Ozurdex) are used to treat macular edema following RVO. Although the pipeline for emerging RVO therapies is sparse, commercial opportunity exists for therapies with a longer dosing duration, greater efficacy, efficacy in treatment-resistant patients, and that are administered less invasively.


  • What diagnostic tests are used to characterize RVO patients, and how are different patient subtypes treated?
  • What are the key areas of unmet need and opportunity in the RVO market?
  • What are the key drivers and limiters in the RVO market?
  • What influence does each major player hold over the RVO market?
  • How is the RVO market expected to change over the next ten years?


United States


3 KOL interviews in April 2019


Regeneron, Roche/Genentech, Allergan, Novartis, Aerie Pharmaceuticals, Cerevast Medical, Taiwan Liposome Company, Kodiak Sciences

KEY DRUGS COVERED Avastin, Eylea, Lucentis, Ozurdex, brolucizumab, AR-1105, TLC399, KSI-301


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