Chronic hand eczema (CHE) is a painful and debilitating form of eczema localized to the hands that can seriously impact a patient’s quality of life. No prescription therapies are yet available for CHE; rather, current treatment is focused on topical or systemic corticosteroids, oral immunosuppressants, or, in some cases, off-label Dupixent. However, the FDA recently granted fast-track status to two emerging JAK inhibitors, one topical and one oral, raising physicians’ hopes for new treatments for CHE. Physicians treating CHE are enthusiastic about having more topical treatments and report a high level of unmet need for safe, effective treatments, with a slight preference for topical therapy.
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