The migraine market is comprised of an array of prescription acute and prophylactic treatments. Today, oral triptan products—the gold standard of acute treatment—already do, or will, face generic competition during our forecast period. Nevertheless, we expect the launch of several emerging therapies including promising nontriptan alternatives—among them Eli Lilly’s 5-HT1F receptor agonist, lasmiditan, and two calcitonin gene-related peptide (CGRP) receptor antagonists, Allergan’s ubrogepant, and Biohaven’s rimegepant—will support future growth in the large acute treatment segment. However, the launch of four premium-priced anti-CGRP MAbs for migraine prophylaxis in both episodic and chronic migraineurs will be the main driver of multi-billion-dollar sales growth in the market; these drugs follow in the footsteps of Allergan’s Botox, which showcases the commercial opportunity that new brands offering valued alternatives can seize in the otherwise generic prophylaxis segment.
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