Malignant Melanoma – Current Treatment – Detailed, Expanded Analysis (US)

Disease stage, primary tumor resectability, and BRAF mutation status are key parameters influencing the treatment paradigm of malignant melanoma patients. BRAF/MEK inhibitor combination regimens, such as Roche / Genentech’s Zelboraf + Cotellic ± Tecentriq, Novartis’ Tafinlar + Mekinist, and Pfizer’s Braftovi + Mektovi, are key treatment options for malignant melanoma patients harboring BRAF mutations, while immune checkpoint inhibitors, Keytruda (Merck & Co.) and Opdivo ± Yervoy (Bristol Myers Squibb), offer therapeutic options to patients regardless of mutation status. Intratumoral treatment options are limited to Amgen’s oncolytic viral therapy Imlygic, available only to patients with injectable lesions that cannot be resected. This content explores key factors driving surveyed medical oncologists’ prescribing decisions when treating malignant melanoma patients


  • What are the current treatment practices in the adjuvant setting and factors influencing the use of BRAF/MEK inhibitors versus anti-PD-1 therapy?
  • What is the uptake of immune checkpoint inhibitors and BRAF/MEK inhibitors for the treatment of BRAF-mutation-positive malignant melanoma patients?
  • How do drug treatment rates vary across key drug-treated patient populations, according to the stage of disease and line of therapy?
  • What drivers and constraints influence treatment decisions in the unresectable or metastatic setting for key targeted therapies?


Current Treatment: Physician Insights provides physician insights on treatment dynamics, prescribing behavior, and drivers of brand use so that marketers can create specific messaging around these treatment dynamics to more effectively increase or defend their market position.

Markets covered: United States.

Primary research: Survey of 102 U.S. medical oncologists in March 2022.

Key drugs covered: Keytruda, Opdivo ± Yervoy, Zelboraf, Cotellic, Tafinlar, Mekinist, Braftovi, Mektovi, Imlygic.