Age-related macular degeneration (AMD) is a degenerative and progressive ocular disease that diminishes central visual acuity as a result of photoreceptor degeneration in the macula. The wet AMD market has long been dominated by three anti-vascular endothelial growth factors (VEGFs), including Roche / Genentech / Chugai’s off-label compounded Avastin, Roche / Genentech / Novartis’s Lucentis, and Regeneron / Bayer HealthCare / Santen’s Eylea. We expect newer entrants to the market, Roche / Chugai’s Vabysmo (faricimab) and Regeneron / Bayer’s Eylea HD to continue to experience strong uptake, driven mostly by their advantageous dosing regimen. Competition will increase in the wet AMD market with the launch of emerging therapies including aflibercept biosimilars and Regenxbio / AbbVie’s ABBV-RGX-314, promising lower cost and longer dosing intervals, respectively. By contrast, the management of geographic atrophy (GA) is limited to Apellis’s Syfovre and Astellas’s Izervay, which launched in the United States in 2023.
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Content highlights
Markets covered: United States, France, Germany, Italy, Spain, United Kingdom, and Japan.
Primary research: 29 country-specific interviews with thought-leading retinal specialists. Supported by survey data collected for this and other Clarivate research.
Epidemiology: Total prevalence of late AMD, by country, segmented by GA and wet AMD subpopulations, including diagnosed and drug-treated rates.
Forecast: 10-year, annualized, drug-level sales and patient share of key GA and wet AMD therapies through 2032, segmented by brands / biosimilars and epidemiological subpopulations.
Emerging therapies: Phase 3 / PR: 7 drugs; Phase 2: 17 drugs; coverage of select Phase 1 products.
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Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.
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