Coronary Heart Disease – Current Treatment – Detailed, Expanded Analysis: Treatment Algorithms: Claims Data Analysis – Stable Angina (US)
May 2019
Stable angina is the most common clinically evident manifestation of coronary heart disease (CHD); it is present in almost half of all prevalent CHD cases. The aim of chronic medical therapy is to minimize symptoms and prevent CHD progression. Acute attacks of stable angina are typically managed with nitrates, while first-line chronic antianginal treatment typically consists of beta blockers, long-acting nitrates, or calcium channel blockers. The branded antianginal drug Ranexa (ranolazine) is used in later lines when initial treatment is unsuccessful. Meanwhile, antiplatelet agents, statins, and ACE inhibitors are typically used to prevent CV events. Using a longitudinal claims data analysis, we demonstrate how stable angina is being treated in the United States and provide insights into what is driving current prescribing practices for newly diagnosed and recently treated patients.
QUESTIONS ANSWERED
- What patient shares do key therapies and brands garner by line of therapy in newly diagnosed stable angina patients?
- What are the quarterly trends in prescribing among recently treated and newly diagnosed stable angina patients?
- How has stable angina been integrated into the treatment algorithm and what is its source of business?
- What percentage of stable angina patients receive drug therapy within one year of diagnosis, and how quickly? What percentage of patients progress to later lines of therapy within one year of diagnosis?
- What percentage of stable angina patients are treated with monotherapy vs. combination therapy? What are the most commonly used combinations?
- What are the product-level compliance and persistency rates among drug-treated stable angina patients?
Geography: United States
Real World Data: Longitudinal patient-level claims data analysis
Key Drugs Covered: Beta blockers, calcium channel blockers, nitrates, antiplatelet agents, statins, ACE inhibitors, Ranexa (ranolazine).
Key Analysis Provided: Brand/therapy usage across longitudinal patient sample. Newly diagnosed patient analysis. Treatment initiation and progression. Line of therapy analysis. Combination therapy analysis. Source of business for recently treated patients. Persistency and compliance analysis. Product-level patient flowcharts.
PRODUCT DESCRIPTION: Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data, so you can accurately assess your source of business, benchmark usage against competitors, and quantify areas of opportunity for your marketed or emerging brand.
Kahkashan Resham, Ph.D., is a senior research associate on the Cardiovascular, Metabolic, and Renal Disorders team at DRG, part of Clarivate. She obtained her doctorate in pharmacology from the National Institute of Pharmaceutical Education and Research (NIPER) in Nagar, India. She completed her M. Pharm. at NIPER in Hyderabad and was awarded a gold medal for securing first rank at the institute. She holds a bachelor’s degree in pharmacy from the Birla Institute of Technology in Ranchi, India. Dr. Resham has also published several peer-reviewed research articles on drug metabolism, diabetes, and chemotherapy-induced peripheral neuropathic pain.