Narcolepsy – Current Treatment – Detailed, Expanded Analysis: Treatment Algorithms Claims Data Analysis (US)

Several therapies from a range of drug classes are available to address the symptoms of narcolepsy; these symptoms include excessive daytime sleepiness (EDS) and cataplexy. Despite the availability of many pharmacological treatments, a large proportion of patients have inadequate control of their narcolepsy symptoms, leaving opportunity for new agents to address these shortcomings. Given that treatment is highly individualized and complex, understanding the use of current therapies in the nuanced narcolepsy treatment algorithm ahead of anticipated product launches is essential. Our Treatment Algorithms research leverages national patient-level claims data to explore the uptake and use of key therapies in narcolepsy (such as modafinil, armodafinil, psychostimulants, antidepressants, the oxybates) and agents approved for the treatment of EDS or EDS and cataplexy symptoms in narcolepsy (such as Harmony Biosciences’ Wakix, Jazz Pharmaceuticals’ Xyrem and Xywav, and Axsome’s Sunosi) in both newly diagnosed and recently treated patients.


  • What patient shares do key therapies and brands garner by line of therapy in newly diagnosed narcolepsy patients? What are the quarterly trends in prescribing among recently treated and newly diagnosed narcolepsy patients?
  • How have branded agents such as Harmony Biosciences’ Wakix, Axsome’s Sunosi, and Jazz Pharmaceuticals’ Xyrem and Xywav been integrated into the treatment algorithm, and what are their sources of business?
  • What percentage of narcolepsy patients receive drug therapy within four years of diagnosis, and how quickly? What percentage of patients progress to later lines of therapy within four years of diagnosis?
  • What percentage of narcolepsy patients are treated with monotherapy versus combination therapy? What are the most commonly used combinations?
  • What are the product-level compliance and persistency rates among drug-treated patients?


Geographies: United States

Real-world data: Longitudinal patient-level claims data analysis

Key drugs covered: armodafinil, modafinil, Sunosi, Vyvanse, Xyrem, Xywav, Wakix

Key companies covered: Axsome, Eli Lilly, Harmony Biosciences, Jazz Pharmaceuticals, Takeda, Teva

Key analysis provided:

  • Brand / therapy usage across longitudinal patient sample.
  • Newly diagnosed patient analysis.
  • Treatment initiation and progression.
  • Line of therapy analysis.
  • Combination therapy analysis.
  • Source of business for recently treated patients.
  • Persistency and compliance analysis.
  • Product-level patient flowcharts.


Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data so that marketers can accurately assess their source of business, benchmark usage against competitors, and quantify areas of opportunity for their marketed or emerging brand.


The Treatment Algorithms dashboard is an interactive supplement to our PowerPoint-based claims data analysis reports and retains the full set of analyses included in the reports (i.e., newly diagnosed patients, recently treated patients, persistency, and compliance). The dashboard allows for easier navigation of data visualizations and provides more detailed analyses examining the flow of treatment regimens in newly diagnosed and recently treated patients.

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