Owing to the large size of the advanced/metastatic, HR-positive/HER2-negative breast cancer market, as well as the long durations of treatment typically associated with treating these patients, this subpopulation is of high commercial interest to drug developers. Two premium-priced targeted therapies have received FDA approval specifically for this population; Ibrance (Pfizer’s palbociclib), a CDK4/6 inhibitor, and Afinitor (Novartis’s everolimus), an mTOR inhibitor, are both first-in-class agents in this market and represent the beginning of a new wave of targeted therapies being investigated in combination with hormonal therapy for the treatment of this disease. Both current and emerging premium-priced therapies in this market segment face the challenge of wresting market share from heavily genericized and less-expensive hormonal agents, which represent a standard of care. In the context of escalating drug costs within the HR-positive/HER2-negative breast cancer population, devising a smart pricing strategy for novel therapies will be crucial to ensure market access, secure reimbursement, maximize uptake, and realize commercial potential.
This report, titled The Escalating Cost of Treating HR-Positive/HER2-Negative Breast Cancer: U.S. Physician and Payer Perception of Premium-Priced Prescribing, captures surveyed medical oncologists’ and payers’ views on anticipated prescribing and reimbursement barriers for current and emerging therapies for HR+/HER2- breast cancer.
Markets covered: United States.
Primary research: Online survey with 100 medical oncologists and 30 MCO PDs/MDs.
Emerging therapies: Phase III: 4 drugs.