New Knowledge area: Drug Metabolism
- Get a better understanding of metabolic pathways of potential drugs in humans
- Identify or predict the main enzyme responsible for the metabolism
- Predict the generation of electrophilic reactive metabolites
- Understand metabolic pathways in preclinical species
Use case: Understand the metabolism of a given drug; Identify enzymes responsible for the metabolism; Predict potential interactions
- Search by Estazolam (short-term treatment for insomnia) in Drug Metabolism to retrieve the related metabolic reactions. Click on the blue arrow on the right to expand the information about a given reaction or Expand all.
2. Click on View Network icon to see in a schematic way all reactions related to Estazolam metabolism.
By clicking on a node, you can see the chemical structure on the left or move the node in the network.
By clicking on “Go to network reactions”, you can see the information related to all reactions within the network in the results page.
- In this example, we can see that there is one reaction catalyzed by CYP3A4, so inhibitors of CYP3A4 could interact with estazolam.
- If we go to Estazolam record and to the related Drug-Drug interaction records, we can see that an inhibitor of CYP3A4, cobicistat, increases the PK exposure of estazolam, which can lead to AE.
Biomarker Clinical Validity:
- Filter biomarkers for those used in Clinical Trials; and by trial design and phase
- Visualize biomarker distribution in clinical trials with the Overview graphs
- Explore details with links from biomarkers to Cortellis Clinical Trials Intelligence
More informative Keep me posted e-mail alerts: You don’t need to go to the Updates history or to a specific record to find what has changed. Instead, all information is provided within the notification e-mail allowing you to identify the interesting changes at one glance.
New fields in Patent results page:
- Mechanism of action of the drugs linked to the patent
- Both the original patent abstract and the abstract written by our editorial experts (Drug Discovery abstract) are now displayed within the results page. This may allow you to easily “scan” your search results to find your patents of interest.
Feel free to hide these columns if you are not interested in those.
Biological processes in Genes & Targets:
- Use the new field “Biological process” in both the Advanced Search and Filters to retrieve only those Genes & Targets involved in the biological processes of interest
- Explore the main Biological processes in which your target of interest is involved
- Explore the main Biological processes in which the targets of drugs similar to your own structure or containing the same substructure are involved
Biological processes from Entrez Gene for which there is experimental evidence are displayed. These are the Experimental evidence codes considered: Inferred from Experiment (EXP), Inferred from Direct Assay (IDA), Inferred from Physical Interaction (IPI), Inferred from Mutant Phenotype (IMP), Inferred from Genetic Interaction (IGI), and Inferred from Expression Pattern (IEP). In addition, only Traceable Author Statement (TAS) processed are included.
Drugs & Biologics:
- Natural source information included in the PDF export.
- ChemDraw structure editor updated to the latest version. This fixes the bug that prevented ChemDraw from loading when using Windows 10 + Chrome.