Migraine – Unmet Need – Detailed, Expanded Analysis Acute Migraine
A range of oral and nonoral triptans (e.g., sumatriptan) are available for the acute treatment of migraine and are entrenched in medical practice. However, triptans have noted clinical shortcomings in efficacy and adverse events that create opportunities for new and improved acute migraine drugs—three of which entered the U.S. market in H1 2020. These agents became the first migraine-specific acute therapies to be approved in nearly two decades. This report provides quantitative insight into neurologists’ perceptions of key treatment drivers and goals in the acute management of migraine and the current level of unmet need in this area. We analyze the commercial opportunities and how new / emerging compounds may capitalize on these opportunities.
QUESTIONS ANSWERED
- What are the treatment drivers and goals in the management of acute migraine?
- What drug attributes are key influences, which have limited impact, and which are hidden opportunities?
- How do current therapies perform on key treatment drivers and goals?
- What are the prevailing areas of unmet need and opportunity in the acute management of migraine?
- What trade-offs across different clinical attributes and price are acceptable to U.S. and European neurologists for a hypothetical new drug for the acute treatment of migraine?
PRODUCT DESCRIPTION
Unmet Need provides quantitative insight into U.S. and European physician perceptions of key treatment drivers and goals and the current level of unmet need for a specific disease. Commercial opportunities are analyzed, and the extent to which emerging therapies may capitalize on these opportunities is evaluated.
Markets covered: United States, United Kingdom, France, Germany.
Primary research: Survey of 60 U.S. and 30 European neurologists fielded in August 2020.
Key drugs: Triptans (e.g., sumatriptan [multiple formulations]), DHE nasal spray, Reyvow, Ubrelvy, and Nurtec ODT.
Table of contents
- Migraine - Unmet Need - Detailed, Expanded Analysis Acute Migraine
- Executive Summary
- Introduction
- Treatment Drivers and Goals
- Key Findings: Attribute Importance
- Relative Importance of Efficacy, Safety and Tolerability, Convenience of Administration, and Nonclinical Attributes to Surveyed Neurologists' Prescribing Decisions in Acute Migraine
- Importance of Efficacy Attributes to Prescribing Decisions in Treatment of Acute Migraine: United States
- Importance of Efficacy Attributes to Prescribing Decisions in Treatment of Acute Migraine: Europe
- Importance of Safety and Tolerability Attributes to Prescribing Decisions in Treatment of Acute Migraine: United States
- Importance of Safety and Tolerability Attributes to Prescribing Decisions in Treatment of Acute Migraine: Europe
- Importance of Convenience of Administration Attributes to Prescribing Decisions in Treatment of Acute Migraine: United States
- Importance of Convenience of Administration Attributes to Prescribing Decisions in Treatment of Acute Migraine: Europe
- Importance of Nonclinical Factors to Prescribing Decisions in Treatment of Acute Migraine: United States
- Importance of Nonclinical Factors to Prescribing Decisions in Treatment of Acute Migraine: Europe
- Key Findings: Stated vs. Derived Importance
- Stated vs. Derived Importance of Key Efficacy, Safety and Tolerability, Convenience of Administration, and Nonclinical Attributes to Prescribing Decisions in Acute Migraine: United States
- Stated vs. Derived Importance of Key Efficacy, Safety and Tolerability, Convenience of Administration, and Nonclinical Attributes to Prescribing Decisions in Acute Migraine: Europe
- Product Performance Against Treatment Drivers and Goals
- Key Findings
- Overall Performance of Key Therapies for Acute Migraine: United States
- Overall Performance of Key Therapies for Acute Migraine: Europe
- Mean Overall Performance of Key Therapies for Acute Migraine: United States and Europe
- Relative Performance of Key Therapies for Acute Migraine Across Select Efficacy Attributes: United States
- Relative Performance of Key Therapies for Acute Migraine Across Select Efficacy Attributes: Europe
- Relative Performance of Key Therapies for Acute Migraine Across Select Safety and Tolerability Attributes: United States
- Relative Performance of Key Therapies for Acute Migraine Across Select Safety and Tolerability Attributes: Europe
- Relative Performance of Key Therapies for Acute Migraine Across Select Convenience of Administration Attributes: United States
- Relative Performance of Key Therapies for Acute Migraine Across Select Convenience of Administration Attributes: Europe
- Relative Performance of Key Therapies for Acute Migraine Across Select Nonclinical Attributes: United States
- Relative Performance of Key Therapies for Acute Migraine Across Select Nonclinical Attributes: Europe
- Assessment of Unmet Need
- Key Findings: Unmet Need in Acute Treatment of Migraine
- Surveyed Neurologistsu2019 Satisfaction with the Performance of Key Therapies for Acute Migraine on Efficacy, Safety and Tolerability, Convenience of Administration, and Nonclinical Factors: United States
- Surveyed Neurologistsu2019 Satisfaction with the Performance of Key Therapies for Acute Migraine on Efficacy, Safety and Tolerability, Convenience of Administration, and Nonclinical Factors: Europe
- Surveyed Neurologists' Ascribed Level of Unmet Need Across Key Efficacy Attributes in Acute Migraine: United States
- Surveyed Neurologists' Ascribed Level of Unmet Need Across Key Efficacy Attributes in Acute Migraine: Europe
- Surveyed Neurologists' Ascribed Level of Unmet Need Across Key Safety and Tolerability Attributes in Acute Migraine: United States
- Surveyed Neurologists' Ascribed Level of Unmet Need Across Key Safety and Tolerability Attributes in Acute Migraine: Europe
- Surveyed Neurologists' Ascribed Level of Unmet Need Across Key Convenience of Administration Attributes in Acute Migraine: United States
- Surveyed Neurologists' Ascribed Level of Unmet Need Across Key Convenience of Administration Attributes in Acute Migraine: Europe
- Surveyed Neurologists' Ascribed Level of Unmet Need Across Key Nonclinical Factors in Acute Migraine: United States
- Surveyed Neurologists' Ascribed Level of Unmet Need Across Key Nonclinical Factors in Acute Migraine: Europe
- Key Findings: Unmet Need in Migraine and Related Indications
- Surveyed Neurologists' Ascribed Level of Unmet Need in Migraine and Related Indications: United States
- Surveyed Neurologists' Ascribed Level of Unmet Need in Migraine and Related Indications: Europe
- Opportunity Analysis
- Target Product Profiles
- Appendix
- 2020 TPP Simulator Acute Migraine
Joyce Spadafora, A.L.M., is a senior analyst on the CNS/Ophthalmology Disorders team. She authors content on various chronic pain, psychiatric, and neurological indications. Prior to joining the company, she spent several years in the biotech industry focusing on new product development and consulting. She holds a master’s degree in extension studies in psychology from Harvard University and a bachelor’s of science in mechanical engineering with biology from the Massachusetts Institute of Technology.