Research Reports | Market Assessment
April 2015

Idiopathic Pulmonary Fibrosis | Niche and Rare Pharmacor | G7 | 2015

Idiopathic pulmonary fibrosis (IPF), although a rare disease, is one of the most common interstitial lung diseases (ILDs) and is characterized by irreversible loss of lung function leading to high morbidity and mortality. IPF usually affects people aged 50 or older and is associated with poor prognosis and most patients die within 3-5 years of diagnosis. Experts interviewed for this report note that the etiology of IPF is unclear but that there is growing consensus that epithelial injury followed by abnormal wound healing can lead to IPF. In 2011, Roche/InterMune’s Esbriet (pirfenidone) became the first putative disease-modifying therapy approved for the treatment of mild-to-moderate adult IPF patients in the European Union. In October 2014, the U.S. FDA followed suit by approving both Esbriet and Boehringer Ingelheim’s Ofev (nintedanib) for IPF. With EMA approval of Ofev in January 2015, the stage is set for a fierce head-to-head battle as physicians incorporate these new treatment options and additional competitors rush to enter the growing IPF therapeutics market.

This report provides an overview of the IPF market in the United States and five major European markets (France, Germany, Italy, Spain, and the United Kingdom), including a comprehensive analysis of patient populations, current therapies and medical practice, and opportunities for emerging therapies. The findings described in this report are derived from detailed interviews with expert U.S. and European pulmonologists, comprehensive secondary research, and best-in-class epidemiological analysis. This report provides deep insights into this complex and evolving clinical space and includes a detailed analysis of specific opportunities for current and emerging therapies, including experts’ views on which unmet needs have not yet been addressed by developers of new therapies.

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