Pancreatic cancer is a notoriously aggressive and hard-to-treat malignancy; the five-year survival rate is around 10%. Treatment options for pancreatic cancer are limited to surgery, radiation, and chemotherapies; thus, demand is high for safer, more-efficacious drugs. FOLFIRINOX and Bristol Myers Squibb’s Abraxane with gemcitabine therapy are cornerstone treatments in the first line. While Merrimack’s Onivyde in combination with 5-FU plus leucovorin has carved out a niche in the second-line setting for patients who failed prior gemcitabine-based therapy; Keytruda is a recommended treatment option in the second line for pancreatic cancer patients with MSI-H or dMMR tumors. However, these therapies offer only modest survival benefits (overall survival is less than one year). AstraZeneca / Merck’s Lynparza is gaining traction as a targeted maintenance therapy for germline BRCA mutations. Although current treatment is dominated by chemotherapies, the pancreatic cancer market is expected to benefit from targeted therapies, mainly kinase inhibitors (Masiviera), monoclonal antibodies (pamrevlumab), biomarker-driven therapies, and launches of novel agents with new mechanisms of action, which will additionally boost market growth over the 2020-2030 forecast period.
Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.
Markets covered: United States, France, Germany, Italy, Spain, United Kingdom, Japan.
Primary research: 19 interviews with experts and country-specific surveys with medical oncologists (~30 per country) who treat pancreatic cancer and PNETs.
Epidemiology: Diagnosed and recurrent incidence of renal cell carcinoma by country, segmented by drug-treatable and -treated population and lines of therapy.
Population segments in market forecast: Stage I/II, stage III, first-line, and second-line for metastatic pancreatic adenocarcinoma and pancreatic neuroendocrine tumors.
Emerging therapies: Phase I/II: 12 drugs; Phase III: 6 drugs.
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