The ovarian cancer treatment algorithm is rapidly evolving. For decades, chemotherapy was the standard of care, but with the introduction of Roche / Genentech / Chugai’s angiogenesis inhibitor Avastin and the PARP inhibitors Lynparza (AstraZeneca / Merck Sharp & Dohme), Rubraca (Clovis Oncology), and Zejula (GlaxoSmithKline / Tesaro), treatment is moving toward a targeted approach. We anticipate that the PARP and angiogenesis inhibitor stronghold will continue throughout the forecast period, principally as part of combination regimens with immune checkpoint inhibitors. Additionally, multiple emerging therapies are set to have an impact on the later-line treatment of ovarian cancer.
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