Chronic Kidney Disease – Landscape & Forecast – Disease Landscape & Forecast

Chronic kidney disease (CKD) refers to a set of heterogenous disorders that affect the structure and function of the kidneys. The CKD drug market comprises a wide variety of antihypertensive agents and SGLT-2 inhibitors, which are intended to delay the progression of kidney damage. RAAS inhibitors are the standard of care for CKD. In 2021, AstraZeneca’s Farxiga (dapagliflozin) became the first SGLT-2 inhibitor to demonstrate a renoprotective effect in a dedicated CKD outcomes trial and to receive formal approval from the FDA for the treatment of CKD irrespective of the presence or absence of diabetes. In 2022, Eli Lilly’s Jardiance (empagliflozin) demonstrated renoprotective benefits among CKD patients in the EMPA-KIDNEY trial; this SGLT-2 inhibitor is expected to receive a label expansion to CKD in 2023. Johnson & Johnson’s Invokana (canagliflozin) also demonstrated renoprotective benefits in diabetic patients with CKD in the CREDENCE trial. Thus, SGLT-2 inhibitors are set to play an increasingly important role in CKD treatment. In 2021, Bayer’s Kerendia (finerenone), a mineralocorticoid receptor antagonist, was approved for CKD after demonstrating renoprotective and cardioprotective benefits in type 2 diabetes patients with CKD in the FIDELIO-DKD and FIGARO-DKD trials. Supported by insights from thought leaders, we analyze the challenges associated with marketing drugs to treat an increasingly dynamic and complex disease.

Questions answered

  • Does the inclusion of cardiovascular endpoints in clinical trials of select CKD therapies confer a competitive advantage once the therapies become commercially available?
  • Are SGLT-2 inhibitors set to become the standard-of-care therapy for CKD?
  • How do KOLs view the advantages and disadvantages of current therapies and the mechanisms of action of emerging therapies?
  • What are the greatest unmet needs in CKD? Which drugs in development will fulfill these unmet needs?
  • What market access and reimbursement challenges will the emerging therapies face in the G7? How will these challenges influence their uptake?

Product description

Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.

Solution enhancement

Disease Landscape & Forecast will be updated throughout the year to provide timely insights and analyses as material indication-specific news and events unfold.

Additionally, Disease Landscape & Forecast introduces a new Drug Pipeline chapter with real-time, global pipeline intelligence content directly from Cortellis. This chapter is updated daily and features interactive figures that can be easily downloaded for detailed analysis or presentations.

Table of contents

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