The ulcerative colitis (UC) market is expected to grow steadily over the next decade. The entry of first-in-UC oral therapies (e.g., Pfizer’s Xeljanz) for the moderate to severe population, together with additional emerging agents with novel MOAs and a general increase in the use of biologics, will help to drive market growth. In particular, the availability of non-TNF biologics (e.g., Takeda’s Entyvio) expands physicians’ treatment armamentarium and intensifies market competition. In balance with these factors, the entry of generics for leading branded conventional agents (e.g., Shire’s Lialda), continuing generic erosion of other conventional agents, and additional entries/expanded uses of less expensive biosimilar TNF-alpha inhibitors (e.g., Pfizer’s Inflectra, Amgen’s Amjevita) will constrain the UC market. Indeed, emerging therapies looking to penetrate this market will need to be clearly differentiated from competitors.
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