Bipolar disorder (BPD) is a spectrum disorder that encompasses two symptom domains: mania and depression. BPD treatment is usually initiated with atypical antipsychotics and antiepileptic drugs (AEDs); their long-standing stronghold as patient-share leaders contributes to the challenges that branded therapies face entering this crowded generic market. However, treatments with the potential to sufficiently address mania and depression will drive growth of the market. Newer-to-market therapies (e.g., Allergan/Gedeon Richter’s Vraylar/Reagila, Lundbeck/Otsuka Pharmaceutical’s Rexulti/RXulti) continue to be incorporated in the treatment paradigm, and emerging therapies (e.g., NeuroRx’s NRX-100/NRX-101) are hoping to demonstrate their ability to fulfill additional unmet needs in BPDtreatment.
Product description: Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.
Markets covered: United States, France, Germany, Italy, Spain, United Kingdom, Japan.
Primary research: Eighteen country-specific interviews with thought-leading psychiatrists, supported by survey data collected for this and other DRG research.
Epidemiology: Lifetime prevalence of BPD by country; diagnosed- and drug-treated prevalence of BPD by country.
Emerging therapies: Phase II: 13 drugs; Phase III: 11 drugs; preregistration: 3 drugs; launched: 1 drugs. Coverage of 8 preclinical and Phase I products.
Market forecast features: Ten-year, annualized, patient-based market forecast extending through 2027, segmented by brands/generics.
Key companies: Allergan, Alkermes, AstraZeneca, Eli Lilly, Gedeon Richter, GlaxoSmithKline, Indivior, Janssen, Lundbeck, Minerva Neurosciences, NeuroRx, Noven Pharmaceuticals, Otsuka Pharmaceutical, Pfizer, Sumitomo Dainippon/Sunovion Pharmaceuticals, Takeda Pharmaceutical.
Key drugs: ALKS-3831, ALKS-5461, aripiprazole, esketamine, lamotrigine IR/XR, Latuda (lurasidone), lithium, lumateperone (ITI-007), NRX-100/NRX-101, , Perseris (risperidone one-month depot, RBP-7000), rapastinel, Rexult/RXulti (brexpiprazole), Risperdal Consta (risperidone microspheres depot), roluperidone (MIN-101), Seroquel IR/XR (quetiapine IR/XR), Trintellix/Brintellix (vortioxetine), Vraylar/Reagila (cariprazine), Wellbutrin IR/SR/XL.