The major depressive disorder (MDD) therapy market is crowded and highly genericized. The prominent use of drugs such as selective serotonin reuptake inhibitors (SSRIs) as early-line treatments contributes to the challenges that branded therapies face when entering this market. Brand-only drugs (e.g., Lundbeck / Takeda’s Trintellix / Brintellix, Lundbeck / Otsuka Pharmaceutical’s Rexulti / Rxulti) largely compete for use in treatment-refractory patients. Janssen’s Spravato, one of the most recent entrants into the depression market, offers a fast onset of therapeutic effect compared with the approved therapies, an attribute that fulfills a key unmet need; however, its use for treatment-resistant depression is constrained by multiple factors. Owing to the remaining unmet need, physicians will continue to look to emerging therapies—many of which offer novel mechanisms of action—as potential future treatments in this market.
Geographies: United States, France, Germany, Italy, Spain, United Kingdom, Japan.
Primary research: 34 country-specific interviews with thought-leading psychiatrists; supported by survey data collected for this and other Clarivate research.
Epidemiology: Prevalence of MDD by country; diagnosed / drug-treated prevalence of MDD by country.
Forecast: 10-year, annualized, drug-level sales and patient share of key MDD therapies in 2022-2032, segmented by brands / generics.
Emerging therapies: Phase 3/PR: 8 drugs. Coverage of select early-phase products.
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