Migraine | Current Treatment: Physician Insights | Migraine Prophylaxis | EU5 | 2018

According to DRG epidemiology, more than 33 million people in the EU5 suffer from migraines and over 10% of migraineurs suffer from chronic migraine (CM). Migraine prophylaxis is a core treatment approach for high-frequency EM and CM patients to reduce migraine frequency, severity, and duration. Drug treatment primarily includes a mix of off-label and approved AEDs, beta blockers, TCAs, and Botox (Allergan’s onabotulinumtoxinA), the only agent approved specifically for CM. With many agents to choose from and a heterogeneous patient population, prophylactic treatment is individualized, complex, and evolves over time. Understanding patient pathways and drivers of treatment decision-making is key for new players bringing novel brands to this large and underserved, but mostly generic drug, market.


  • What patient share do key therapies and brands garner by line of therapy in migraine patients initiating prophylaxis?
  • What are the drivers and constraints influencing physicians’ treatment decisions for migraine prophylaxis across the EU5? How are patients being treated across different lines of therapy?
  • How is Botox integrated into the treatment algorithm?
  • What percentage of migraine patients are treated with monotherapy versus combination therapy? What are the most widely used combination therapies?
  • How do physicians think their prescribing will change upon the launch of anti-CGRPMAbs?


Current Treatment: Physician Insights provides physician insights on treatment dynamics, prescribing behavior, and drivers of brand use so you can create specific messaging around these treatment dynamics in order to more effectively increase or defend your market position.

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