China has the highest incidence of gastroesophageal cancer globally, and therapeutic options are limited. Only five targeted agents are approved for treatment—trastuzumab (Roche’s Herceptin, generics) as the first-line standard of care for HER2-positive gastric and gastroesophageal junction (GEJ) adenocarcinoma patients, apatinib (Jiangsu Hengrui Medicine’s AiTan) and nivolumab (BMS’s Opdivo) for third-line gastric and GEJ adenocarcinoma patients, pembrolizumab (Merck’s Keytruda) for second-line esophageal squamous cell carcinoma patients, and camrelizumab (Jiangsu Hengrui Medicine’s AiRuiKa) for first- and second-line advanced or metastatic esophageal squamous cell carcinoma. Several novel targeted therapies—including VEGFR inhibitors (Eli Lilly’s Cyramza and Chi-Med’s Elunate), a claudin inhibitor (Ganymed’s zolbetuximab), and several immune checkpoint inhibitors (Innovent Biologics’ Tyvyt, BeiGene’s Baizean, and CStone Pharmaceuticals’ CS1001)—are in preregistration or late-phase trials. The launch and uptake of these agents will lead to significant growth of the gastroesophageal cancer therapy market over the 2021-2031 period. However, the need for additional effective targeted therapies will remain high, representing a lucrative commercial opportunity for developers.
How large is China’s drug-treatable gastroesophageal cancer population, and how will drug-treatment rates change during the forecast period?
Which are the most commercially relevant drugs in China’s gastroesophageal cancer market, and why? What are interviewed experts’ insights into current treatment options?
What are the key market access considerations for therapies in the gastroesophageal cancer pipeline in China? What sales / uptake could they secure in gastroesophageal cancer? What are interviewed experts’ opinions of key emerging therapies?
What are the key drivers and constraints in China’s gastroesophageal cancer therapy market, and how will the market evolve over the forecast period?
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