TNF-α inhibitors (e.g., Janssen's Remicade, AbbVie’s Humira) are well entrenched in the U.S. ulcerative colitis (UC) and Crohn’s disease (CD) markets. Newer therapies that offer alternative treatment options (i.e., Takeda’s Entyvio, Pfizer’s Xeljanz, and Janssen’s Stelara) and the increasing penetration of biosimilar infliximab (e.g., Pfizer’s Inflectra, Merck’s Renflexis) continue to expand the UC / CD treatment landscapes and are shifting UC and CD market dynamics. Additionally, the arrival of emerging agents—some with novel MOAs—including Gilead / Galápagos’ Jyseleca, AbbVie’s Rinvoq and Skyrizi, Janssen’s Tremfya, Eli Lilly’s mirikizumab, Takeda’s darvadstrocel, and BMS’s Zeposia, and physicians’ increasing prescribing of biosimilars will fuel competition and add to pricing pressure. Emerging therapies seeking favorable uptake in UC and/or CD will face an increasing number of market-access challenges.
U.S. Access & Reimbursement provides integrated brand- and disease-level insight on reimbursement dynamics and the impact of U.S. payer policy on physician prescribing behavior in the market access environment, including up-to-date analysis of drug coverage and restriction policies and payer and prescriber perspectives on key marketed drugs and receptivity to emerging therapies.
Key drugs: Remicade, Humira, biosimilar infliximab, Simponi, Cimzia, Entyvio, Stelara, Xeljanz, Rinvoq, Zeposia, Skyrizi, Tremfya, mirikizumab
Key Companies: AbbVie, Bristol-Myers Squibb, Eli Lilly, Janssen, Merck, Pfizer, Takeda, UCB, Celltrion Healthcare, Gilead, Galápagos.