Approved in Europe and the United States, lenacapavir is a first-in-class, long-acting HIV-1 capsid inhibitor for the treatment of multi-drug resistant (MDR) HIV in people who have been heavily treated, a patient population with unmet medical need. Also currently being investigated to treat HIV and for pre-exposure prophylaxis (PrEP), its infrequent dosing and self-administration will likely make it a favored choice in a population with treatment adherence challenges.
Lenacapavir inhibits HIV-1 at multiple stages during its lifecycle (capsid assembly, transport and disassembly), differentiating it from most other antivirals that target only one stage of viral replication and opening a new avenue for developing long-acting therapies for people living with or at risk of HIV.
December 27, 2022:
• For heavily-treatment-experienced adult patients with MDR HIV-1 infection: Marketing authorization: U.S.
Actual and expected launch:
• 2022: Europe
• 2023: United States
• 2028: Japan
Patents estimated to expire beginning in 2028
Access global intelligence, advanced analytics and global experts from Clarivate.