Foscarbidopa/foslevodopa, in development by AbbVie, is a novel reformulation of the gold-standard Parkinson’s disease treatment (carbidopa/levodopa) delivered via a subcutaneous pump for the treatment of motor fluctuations in advanced Parkinson’s disease. In addition to serving a niche group of patients with high unmet need, it offers better efficacy than orally administered carbidopa-levodopa, dosing flexibility and a more convenient pump than existing and upcoming competitors, and it is backed by AbbVie’s experience in this space via its own DUOPA™/DUODOPA® (carbidopa/levodopa enteral suspension).
If launched when predicted, foscarbidopa/foslevodopa will be the first subcutaneous carbidopa/levodopa infusion to market, addressing noted shortcomings with DUOPA/DUODOPA (e.g., surgical requirements, complications). Although many current treatment options manage motor fluctuations of Parkinson’s disease, patients with advanced Parksinon’s disease often achieve poor motor control, even with chronic polypharmacy. By stabilizing levodopa levels, AbbVie’s pump will offer a more effective alternative for the right patients.
Expected launch:
• 2023: United States, Europe and Japan
Patents estimated to expire beginning in 2039
Access global intelligence, advanced analytics and global experts from Clarivate.