Major Depressive Disorder (DSM-V) – Landscape & Forecast – Disease Landscape & Forecast (G7)

The major depressive disorder (MDD) therapy market is crowded and highly genericized. The prominent use of generic drugs such as selective serotonin reuptake inhibitors (SSRIs) as early-line treatments contributes to the challenges that branded therapies face when entering this market. Brand-only drugs (e.g., Lundbeck / Takeda’s Trintellix / Brintellix, Lundbeck / Otsuka Pharmaceutical’s Rexulti / Rxulti, AbbVie’s Vraylar / Reagila, Axsome’s Auvelity) largely compete for use in treatment-refractory patients. Johnson & Johnson Innovative Medicine’s Spravato offers a fast onset of therapeutic effect compared with the approved therapies, an attribute that fulfils a key unmet need; however, its use for treatment-resistant depression is constrained by multiple factors. Owing to the remaining unmet needs, physicians will continue to look to emerging therapies—many of which offer novel mechanisms of action—as potential future treatments in this market.

Questions answered

• What is the current size of the MDD therapy market in the G7 countries? What key events will influence the market over the next decade?
• What is the epidemiology of MDD in the G7 countries? What percentage of prevalent patients are diagnosed and drug-treated?
• What factors drive and constrain the use of branded antidepressants and atypical antipsychotics in MDD? Which branded therapy is expected to experience the most commercial success during the forecast period?
• What are the greatest areas of unmet need in the treatment of MDD, and how are emerging therapies expected to address these unmet needs?

Content highlights

Geography: United States, EU5, Japan.

Primary research: Country-specific interviews with thought-leading psychiatrists; survey data collected for this and other Clarivate research

Epidemiology: Prevalence of MDD by country; diagnosed / drug-treated prevalence of MDD by country.

Forecast: 10-year, annualized, drug-level sales and patient share of key MDD therapies through 2034, segmented by brands / generics.

Drug treatments: Coverage of key current and emerging therapies.

Product description

Disease Landscape & Forecast offers comprehensive market intelligence with world-class epidemiology, keen insight into current and emerging therapies, and drug forecasts supported by detailed primary and secondary research, enabling you to:

• Optimize your long-term disease and development strategy.
• Quantify market potential for your pipeline assets and those of your competitors.
• Understand a disease from top to bottom, including key patient populations, the current and future therapeutic landscape, and the evolving market trajectory.
• Gauge the commercial outlook and impact of key market events.