Psoriatic Arthritis | Treatment Algorithms: Claims Data Analysis | US | 2025

Treatment of psoriatic arthritis (PsA) typically begins with conventional DMARDs, such as methotrexate, and progresses to more-potent biologics and/or targeted oral therapies as needed. The U.S. market for conventional DMARD-refractory PsA has a wide array of effective treatments, including eight TNF-α inhibitors, three IL-17 inhibitors, an IL-12/23 inhibitor, three IL-23 inhibitors, and three targeted oral agents (a PDE4 inhibitor and two JAK inhibitors). The launch of adalimumab biosimilars has also expanded physicians’ treatment choices for PsA, intensifying the competition in an already saturated market.

QUESTIONS ANSWERED

• What patient shares do key therapies and brands garner by line of therapy in newly diagnosed PsA patients? What are the quarterly trends in prescribing among recently treated and newly diagnosed PsA patients?
• How have Bimzelx and Rinvoq been integrated into the treatment algorithm, and what are their sources of business?
• What percentage of PsA patients receive drug therapy within two years of diagnosis, and how quickly? What percentage of patients progress to later lines of therapy within two years of diagnosis? What percentage of PsA patients are treated with monotherapy vs. combination therapy? What are the most commonly used combinations?
• What percentage of PsA patients are treated with monotherapy vs. combination therapy? What are the most commonly used combinations?
• What are the product-level compliance and persistency rates among drug-treated patients?

Markets covered: United States

Key companies: AbbVie, Amgen, Johnson & Johnson Innovative Medicine, Novartis, Eli Lilly, Pfizer, Sun Pharma, UCB

Key drugs: Humira, Enbrel, Remicade, biosimilar infliximab, Cimzia, Simponi, Simponi Aria, Stelara, Bimzelx, Cosentyx, Taltz, Tremfya, Skyrizi, Orencia, Otezla, Xeljanz, Rinvoq, methotrexate

Key feature: Dashboard featuring interactive visuals, easy navigation, and expanded analyses

PRODUCT DESCRIPTION

Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data, enabling you to:

• Understand patient flow between lines of therapy.
• Evaluate your brand share against competitors.
• Accurately assess your source of business.
• Quantify opportunities at different stages of the treatment algorithm.

Product enhancement

Treatment Algorithms: Claims Data Analysis leverages Clarivate’s proprietary Real-World Data, which brings larger patient samples, broader payer coverage, and faster availability for more robust and timely analyses. Additionally, we include new patient demographic analyses: age, gender, ethnicity, and region.