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Painful Diabetic Neuropathy – Current Treatment – Treatment Algorithms: Claims Data Analysis – Painful Diabetic Neuropathy (US)

Painful diabetic neuropathy (PDN) is a prevalent complication of diabetes, typically causing persistent burning, tingling, or sharp pain in the extremities. Management relies on a range of established therapies, including antidepressants, antiepileptics, NSAIDs, and opioids, most of which are available as generics. Many patients achieve only partial symptom relief, creating a clear unmet need for new pharmacological approaches. Emerging PDN therapies are targeting novel mechanisms, including Vertex’s Phase 3 Nav1.8 inhibitor, Journavx (suzetrigine). In this competitive, highly generic market, understanding real-world prescribing patterns, physician preferences, and patient outcomes is critical to anticipating adoption trends. The successful launch of a new analgesic requires a detailed understanding of how existing therapies are used and where gaps remain.

QUESTIONS ANSWERED

· What patient shares do key therapies garner by line of therapy in newly diagnosed PDN patients? 

· What percentage of PDN patients receive drug therapy within one year of diagnosis, and how quickly? What percentage of patients progress to later lines of therapy within one year of diagnosis?

· What percentage of PDN patients are treated with monotherapy vs. combination therapy? What are the most commonly used combinations?

· What are the product-level compliance and persistency rates among drug-treated patients?

Markets covered: United States

Key companies: AbbVie, Almatica, Aucta, Averitas, Azurity, BioDelivery Sciences International, Collegium Pharmaceuticals, Kowa, Protega Pharmaceuticals, Sumitomo Pharma, Vertex, Viatris

Key drugs: Gabapentin (Neurontin, generics), tramadol, duloxetine (Cymbalta, generics), pregabalin (Lyrica, generics), Motpoly XR, other antidepressants (e.g., amitriptyline, citalopram, escitalopram), other AEDS (e.g., carbamazepine, topiramate), oral NSAIDs, opioid analgesics (e.g., Belbuca, RoxyBond, Xtampza ER), Qutenza, Gralise, Horizant, Nucynta, ZTlido, Journavx

Key feature: Dashboard featuring interactive visuals, easy navigation, and expanded analyses

PRODUCT DESCRIPTION

Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data, enabling you to:

  • Understand patient flow between lines of therapy.
  • Evaluate your brand share against competitors.
  • Accurately assess your source of business.
  • Quantify opportunities at different stages of the treatment algorithm.

Product enhancement

Treatment Algorithms: Claims Data Analysis leverages Clarivate’s proprietary Real-World Data, which brings larger patient samples, broader payer coverage, and faster availability for more robust and timely analyses. Additionally, we include new patient demographic analyses: age, gender, ethnicity, and region.

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