Acute Coronary Syndrome – Current Treatment – Treatment Algorithms: Claims Data Analysis – Acute Coronary Syndrome: Secondary Prevention (US)

Acute coronary syndrome (ACS) is an umbrella term encompassing myocardial infarction and unstable angina. This report focuses on the secondary prevention of ACS (post-ACS), aimed at preventing recurrent CV events, adverse cardiac remodeling, and prolonging survival. The current post-ACS drug market is dominated by generic therapies such as aspirin, statins, RAAS inhibitors, and beta blockers. Key brands include PCSK9 inhibitors (evolocumab, alirocumab, inclisiran), ACL inhibitors (bempedoic acid), P2Y12 inhibitors (ticagrelor), anti-inflammatory agents (low-dose colchicine), and prescription omega-3 fatty acids (icosapent ethyl). In this report, we use patient-level claims data to analyze prescribing dynamics in the U.S. post-ACS drug market and provide insights into the factors shaping treatment patterns among newly diagnosed and recently treated patients.

Questions answered

• What patient shares do key therapies and brands garner by line of therapy in newly diagnosed post-ACS patients? What are the quarterly trends in prescribing among recently treated and newly diagnosed post-ACS patients?
• How have PCKS9 inhibitors and bempedoic acid been integrated into the treatment algorithm, and what is their source of business?
• What percentage of post-ACS patients receive drug therapy within one year of diagnosis, and how quickly?
• What percentage of patients progress to later lines of therapy within one year of diagnosis?
• What percentage of post-ACS patients are treated with monotherapy vs. combination therapy? What are the most commonly used combinations?
• What are the product-level compliance and persistency rates among drug-treated patients?

Product description

Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall, using real-world, patient-level claims data, enabling you to:

• Understand patient flow between lines of therapy.
• Evaluate your brand share against competitors.
• Accurately assess your source of business.
• Quantify opportunities at different stages of the treatment algorithm.

Key drugs covered

Evolocumab, alirocumab, inclisiran, bempedoic acid, icosapent ethyl, colchicine ticagrelor

Key analyses:

• Brand / therapy usage across longitudinal patient sample
• Newly diagnosed patient analysis
• Treatment initiation and progression
• Line of therapy analysis
• Combination therapy analysis
• Source of business for recently treated patients
• Persistency and compliance analysis
• Product-level patient flow charts

Product enhancement

Treatment Algorithms: Claims Data Analysis leverages Clarivate’s proprietary Real-World Data, which brings larger patient samples, broader payer coverage, and faster availability for more robust and timely analyses. Additionally, we include new patient demographic analyses: age, gender, ethnicity, and region.