Squamous Cell Carcinoma of the Head and Neck – Landscape & Forecast – Disease Landscape & Forecast (Major Markets)

Squamous cell carcinoma of the head and neck (SCCHN) is the seventh most commonly diagnosed cancer. It encompasses a spectrum of heterogeneous tumors originating at multiple sites in the head and neck. Chemotherapy remains standard in locally advanced SCCHN, but the recent approval of perioperative pembrolizumab is expected to reshape early-stage management. Targeted therapies are frequently prescribed to patients with metastatic disease. The usual treatment algorithm starts with a PD-1-targeting antibody (pembrolizumab [Keytruda / Keytruda Qlex]) for metastatic disease, followed by an EGFR-targeting agent (cetuximab [Erbitux]) after progression. The expected approval of petosemtamab (in combination with pembrolizumab) will significantly impact treatment in the metastatic settings during the 2025-2035 forecast period. Ficlatuzumab (in combination with cetuximab), SC amivantamab (Rybrevant Faspro) and petosemtamab in later-line treatment are expected to further reshape the treatment landscape for patients with metastatic disease. The approval of toripalimab (Loqtorzi) is setting a new treatment paradigm for nasopharyngeal carcinoma (NPC), with strong adoption anticipated. The recently approved penpulimab and tislelizumab (Tevimbra) are expected to see more limited uptake among these patients.

Questions answered

• What are the sizes of the clinically and commercially relevant drug-treatable populations in this market, and how will drug-treatment rates change over time?
• What barriers and drivers will influence the adoption of SCCHN therapies during the forecast period?
• How will the entry of new pembrolizumab-based combinations, such as petosemtamab, impact the treatment for metastatic, first-line SCCHN?
• What are the key market drivers and constraints, and how is the market expected to evolve over the next 10 years?

Product description

Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current and emerging therapies, and drug forecasts supported by detailed primary and secondary research.

Key features

Disease Landscape & Forecast will be updated throughout the year to provide timely insights and analyses as material indication-specific news and events unfold.