Major Depressive Disorder | Treatment Algorithms: Claims Data Analysis | US | 2025
Major depressive disorder (MDD) is a condition heavily treated with an array of drug classes. Although the MDD drug market is dominated by generic therapies, the heterogeneous response of MDD patients to current drugs and the need for more effective therapies create opportunities for branded agents (e.g., Trintellix [Lundbeck / Takeda], Rexulti [Otsuka / Lundbeck], Vraylar [AbbVie], Spravato [Johnson & Johnson Innovative Medicine], Auvelity [Axsome Therapeutics]) to be incorporated into the treatment algorithm. Given MDD’s highly competitive landscape encompassing both long-established and newer-to-market drugs, it is important for drug marketers and developers to understand physicians’ prescribing trends.
Questions answered
- What patient shares do key therapies and brands garner by line of therapy in newly diagnosed MDD patients? What are the quarterly trends in prescribing among recently treated and newly diagnosed MDD patients?
- How have Trintellix, Rexulti, Vraylar, Spravato, and Auvelity been integrated into the treatment algorithm, and what are their sources of business?
- What percentage of MDD patients receive drug therapy within one year of diagnosis, and how quickly? What percentage of patients progress to later lines of therapy within one year of diagnosis?
- What percentage of MDD patients are treated with monotherapy vs. combination therapy? What are the most commonly used combinations?
- What are the product-level compliance and persistency rates among drug-treated patients?
Key drugs covered
Trintellix, Rexulti, Vraylar, Spravato, Auvelity, sertraline, escitalopram, bupropion SR/XL, duloxetine
Product description
Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data, enabling you to:
- Understand patient flow between lines of therapy.
- Evaluate your brand share against competitors.
- Accurately assess your source of business.
- Quantify opportunities at different stages of the treatment algorithm.
Product enhancement
Treatment Algorithms: Claims Data Analysis leverages Clarivate’s proprietary Real-World Data, which brings larger patient samples, broader payer coverage, and faster availability for more robust and timely analyses. Additionally, we include new patient demographic analyses: age, gender, ethnicity, and region.
Key features
Dashboard featuring interactive visuals, easy navigation, and expanded analyses.
Real-world data
Longitudinal patient-level claims data analysis
Key analyses
- Brand / therapy usage across patient sample
- Newly diagnosed patient analysis
- Treatment initiation and progression
- Line of therapy analysis
- Combination therapy analysis
- Source of business for recently treated patients
- Persistency and compliance analysis
- Product-level patient flow charts
