Product logins

Find logins to all Clarivate products below.


Myelodysplastic Syndromes | Access & Reimbursement | US | 2020

Myelodysplastic syndromes (MDS) are a heterogeneous collection of hematopoietic stem cell disorders that result in cytopenias. Based on our survey results, the U.S. reimbursement environment already restricts the prescription of high-priced MDS medications, and treatment costs are set to increase with the expected approval of new agents, including BristolMyers Squibb / Acceleron’s Reblozyl. In this report, we analyze in depth the current and anticipated uptake of MDS therapies. In addition, we examine how MCO formulary decisions and utilization controls on both the pharmacy benefit and medical benefit affect the prescribing of surveyed hematologists.

QUESTIONS ANSWERED

  • What is the coverage status of key MDS medications such as Vidaza, Revlimid, and the ESAs? What are the key drivers of their status?
  • How strong of an impact do reimbursement restrictions have on hematologists’ decision to use less-effective but more-affordable treatment options for MDS? What other factors influence prescribing?
  • Which are the key factors that payers consider before including a drug in their formulary? What changes do payers anticipate in the future?
  • What attributes must an emerging MDS therapy offer to secure favorable coverage and formulary positioning? What impact will luspatercept’s potential approval have on the MDS therapy market?

PRODUCT DESCRIPTION

U.S. Access & Reimbursement provides integrated brand- and disease-level insight on reimbursement dynamics and the impact of U.S. payer policy on physician prescribing behavior in the market access environment, including up-to-date analysis of drug coverage and restriction policies and payer and prescriber perspectives on key marketed drugs and receptivity to emerging therapies.

CONTENT HIGHLIGHTS

Release date: June 2020

Geography: United States

Primary research: Survey of 100 U.S. hematologists and 30 U.S. managed care organization (MCO) pharmacy and medical directors (PDs / MDs).

Fingertip formulary: Formulary coverage and restrictions data for MDS therapies by commercial plans covering approximately 166 million lives and Medicare Part D plans covering 35 million lives nationally.

Key drugs covered: Vidaza, Revlimid, Dacogen, Epogen, Aranesp, Procrit

Key analysis provided:

  • Reimbursement and contracting.
  • Access and prescribing.
  • Opportunities and challenges for emerging therapies.
  • Disease-specific special topic.

Related Market Assessment Reports

Report
Hemophilia A – Current Treatment – Current Treatment: Physician Insights – Hemophilia A with Inhibitors (US)
Development of neutralizing antibodies against factor VIII replacement is the most significant clinical complication in hemophilia A, necessitating specialized and often high-cost management…
Report
Major Depressive Disorder (DSM-V) – Access & Reimbursement – Access & Reimbursement – Major Depressive Disorder (US)
Numerous drugs from multiple drug classes are used as monotherapies and/or adjunctive therapies to treat major depressive disorder (MDD). Early-line treatment is dominated by generically available…
Report
Malignant Melanoma – Unmet Need – Unmet Need – BRAF Wild-Type, Unresectable or Metastatic Malignant Melanoma (US/EU)
Treatment for BRAF wild-type unresectable or metastatic melanoma has been largely shaped by the successive approvals of immune checkpoint inhibitors. Anti-PD-1 agents such as Keytruda (Merck & Co…
Report
Systemic Lupus Erythematosus | Unmet Need | Moderate to Severe Systemic Lupus Erythematosus | US/EU | 2024
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect different organ systems of the body and manifest in a wide range of clinical symptoms, from general fatigue to serious…
Report
Systemic Lupus Erythematosus – Unmet Need – Unmet Need – Moderate to Severe Systemic Lupus Erythematosus (US/EU)
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect different organ systems of the body and manifest in a wide range of clinical symptoms, from general fatigue to serious…