Zepbound has doubled its market share in a year, nearly matching Wegovy at around two in five weight loss prescriptions, DRG Fingertip data shows.
Since July 1, 2025, CVS Caremark has continued to prefer Wegovy on its national formularies while removing Zepbound, which resulted in its formulary coverage dropping 17 points to 83% in a month. For plan formularies administered by CVS Caremark, Wegovy is being increasingly covered, although as a non-preferred restricted drug.
Beyond formulary inclusion, insurers are increasingly relying on utilization management tools. While CVS Caremark has expanded Wegovy coverage, prior authorization requirements have also intensified. Insurers are offering opt-in or limited coverage options for GLP-1s and adding weight and lifestyle management programs or enticing clients with cost guarantees.
Patients are increasingly willing to bypass insurance for weight loss solutions, or seeking holistic and lifestyle-based interventions. A growing number of telemedicine vendors are entering the space, offering convenience and accessibility to patients who can afford to forego coverage.
Implications for key stakeholders
For manufacturers, scaling up production to meet demand and negotiating with insurers to improve coverage terms is critical. Enhancing patient satisfaction and prescribing confidence can boost sales through direct-to-consumer strategies.
Along with aggressive formulary selection, payers will utilize hybrid models combining drug coverage with lifestyle programs and cost guarantees.
Telehealth providers can benefit from leveraging GLP-1 demand to expand service offerings and partnerships, while employer wellness platforms offer an opportunity to integrate weight loss solutions into benefits packages.
DRG Fingertip’s suite of solutions delivers pharmacist-validated, AI-powered visibility into the industry’s most accurate market access intelligence, including coverage, restrictions, source transparency and policy change tracking.
Learn more about the impact of GLP1s in Clarivate’s DRG Fingertip products.
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