Crohn’s Disease | Unmet Need | US/EU | 2019

MARKET OUTLOOK

Treatment of moderate to severe Crohn’s disease (CD) typically begins with safe, albeit often less-efficacious, conventional agents (e.g., 5-ASAs) and progresses to more-potent drugs, such as immunosuppressants and/or biologics. The TNF-α inhibitors (e.g., Janssen’s Remicade, AbbVie’s Humira) are the mainstay of biological treatment for moderate to severe CD. However, these agents have safety risks and efficacy limitations. Two additional biological agents with novel mechanisms of action (i.e., Takeda’s Entyvio, a CAM inhibitor approved in 2014, and Janssen’s Stelara, an IL-12/23 inhibitor approved in 2016) have expanded the treatment options for moderate to severe CD; however, significant need remains, especially for patients refractory to currently available therapies.

QUESTIONS ANSWERED

• What are the treatment drivers and goals for moderate to severe CD?
• In addition to efficacy, what other drug attributes influence physician prescribing behavior the most, and which attributes have limited impact?
• How do TNF-α inhibitors (branded and biosimilars) and novel biologics (i.e., Entyvio and Stelara) perform on treatment drivers and goals?
• What are the prevailing areas of high unmet need and hidden opportunity in moderate to severe CD?
• What trade-offs across different clinical attributes and prices are acceptable to U.S. and European gastroenterologists for a hypothetical new CD drug?

PRODUCT DESCRIPTION

Unmet Need supports clinical development decisions by identifying key attributes and assessing areas of unmet need for a specific disease or subpopulation. Based on surveys with U.S. and European physicians, this report provides insight into key treatment drivers and goals, the performance of current therapies, and the remaining commercial opportunities. Two market scenarios are profiled in detail by DRG experts, and additional customized market scenarios can be evaluated with the corresponding TPP simulator.

Markets covered: United States, United Kingdom, France, Germany

Primary research: Survey of 60 U.S. and 31 European gastroenterologists fielded in January2019.

Key companies:  AbbVie, Galapagos NV, Gilead, Janssen, Merck & Co., Takeda, TiGenix,  Boehringer Ingelheim, Allergan,  Celgene, Roche

Key drugs: Humira, Remicade, Entyvio, Stelara, Cimzia, infliximab biosimilars, adalimumab biosimilars