Bladder Cancer and Upper Tract Urothelial Carcinoma | Disease Landscape & Forecast | G7 | 2023
Immune checkpoint inhibitors have greatly altered the treatment landscape for bladder cancer and upper tract urothelial carcinoma (UTUC). Initially confined to treatment of advanced disease, the anti-PD-1 therapies Keytruda (Merck & Co.) and Opdivo (Bristol Myers Squibb) are now approved in earlier treatment settings. Keytruda is now poised to become the standard of care in the first-line setting in combination with the antibody-drug conjugate Padcev (Seagen / Astellas) in cisplatin-ineligible patients. In the high-risk BCG-unresponsive population, Adstiladrin (Ferring Pharmaceuticals) is the first gene therapy available to treat bladder cancer in the United States. The approval of Bavencio (Merck KGaA / Pfizer) as maintenance therapy for first-line locally advanced or metastatic urothelial carcinoma highlights the expanded use of immune checkpoint inhibitors in all lines of therapy across the geographies covered. The initial entry of antibody-drug conjugates Padcev and Trodelvy (Gilead) has diversified the treatment paradigm for previously treated advanced or metastatic disease. Several new therapies and combinations, anticipated to be approved by 2032, will only intensify the competition in this market.
Question answered
- What are the sizes of the clinically and commercially relevant drug-treatable bladder cancer and UTUC populations, and how will drug-treatment rates change over time?
- How is bladder cancer and upper tract urothelial carcinoma currently treated, and how do their treatment options differ? What are the key advantages and disadvantages of existing drugs? What is the expected market impact of recent approvals?
- Which of the emerging therapies are viewed as most promising, and what sales / uptake could they secure in the bladder cancer and UTUC market?
- What are the key market drivers and constraints, and how will the market evolve over the 10-year forecast period?
Product description
Disease Landscape & Forecast provides comprehensive market intelligence with world-class epidemiology, keen insight into current treatment paradigms, in-depth pipeline assessments, and drug forecasts supported by detailed primary and secondary research.
Solution enhancement
Disease Landscape & Forecast will be updated throughout the year to provide timely insights and analyses as material indication-specific news and events unfold.
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