Chronic Urticaria – Current Treatment – Treatment Algorithms: Claims Data Analysis – Chronic Inducible Urticaria (US)
Chronic inducible urticaria (CIndU) comprises multiple chronic urticaria subtypes triggered by specific external stimuli. Compared with chronic spontaneous urticaria (CSU), CIndU appears to be more resistant to standard-dose antihistamines. However, claims data indicate positive uptake trends for both first- and second-generation antihistamines, such as cyproheptadine and Clarinex. Vistaril and montelukast also remain commonly used, often as part of combination regimens, despite the removal of leukotriene receptor antagonists, including montelukast, from current treatment guidelines. Although no biologics are approved for CIndU, certain agents, including TNF inhibitors, Roche / Novartis’s Xolair, and Sanofi / Regeneron’s Dupixent, are used off-label, primarily in later lines of therapy. Overall, more effective therapies specifically targeting CIndU would likely see meaningful uptake.
Questions answered
- What patient shares do key therapies and brands garner by line of therapy in newly diagnosed CIndU patients? What are the quarterly trends in prescribing among recently treated and newly diagnosed CIndU patients?
- How have Xolair, TNF-alpha inhibitors, and Dupixent been integrated into the treatment algorithm, and what are their sources of business?
- What percentage of CIndU patients receive drug therapy within one year of diagnosis, and how quickly? What percentage of patients progress to later lines of therapy within one year of diagnosis?
- What percentage of CIndU patients are treated with monotherapy vs. combination therapy? What are the most commonly used combinations?
- What are the product-level compliance and persistency rates among drug-treated patients?
Product description
Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data, enabling you to:
- Understand patient flow between lines of therapy.
- Evaluate your brand share against competitors.
- Accurately assess your source of business.
- Quantify opportunities at different stages of the treatment algorithm.
Geography: United States
Real-world data: U.S. pharmacy and medical claims data
Key drugs covered: Allegra, Zyrtec, Xolair, Benadryl, montelukast, Vistaril, Silenor, Humira, Dupixent
Key analyses: Brand / therapy usage across longitudinal patient sample; newly diagnosed patient analysis; treatment initiation and progression; line of therapy analysis; combination therapy analysis; source of business for recently treated patients; persistency and compliance analysis; product-level patient flow charts
Product enhancement
Treatment Algorithms: Claims Data Analysis leverages Clarivate’s proprietary Real-World Data, which brings larger patient samples, broader payer coverage, and faster availability for more robust and timely analyses. Additionally, we include new patient demographic analyses: age, gender, ethnicity, and region.
