Myasthenia Gravis | Treatment Algorithms: Claims Data Analysis | US | 2024

Myasthenia gravis (MG) is a rare neuromuscular disorder caused by specific autoantibodies at the neuromuscular junction targeting—in most patients—acetylcholine receptors. It is characterized by muscle weakness and fatigue. Acetylcholinesterase inhibitors (e.g., pyridostigmine), corticosteroids (e.g., prednisone), and short- and long-term immunosuppressants (e.g., mycophenolate mofetil, azathioprine) are the most prescribed agents to manage the symptoms of MG. Since the launch of eculizumab (Alexion / AstraZeneca’s Soliris) in 2017, a new wave of MG therapies with unique mechanisms of action is starting to affect the treatment landscape in the United States, highlighted by the FDA’s approval of efgartigimod (Argenx’s Vyvgart) in 2021 and its subcutaneous version in 2023, ravulizumab (Alexion / AstraZeneca’s Ultomiris) in 2022, and rozanolixizumab (UCB’s Rystiggo) in 2023. As the treatment landscape for MG continues to evolve, this report offers insight based on real-world claims data into prescribing trends for MG to help new players understand current treatment practices and define the market niche for their emerging products.

Questions answered

• What patient shares do key therapies and brands garner by line of therapy in newly diagnosed MG? What are the quarterly trends in prescribing among recently treated and newly diagnosed MG patients?
• How have the new MG therapies been integrated into the treatment algorithm, and what are their sources of business?
• What percentage of MG patients receive drug therapy within one year of diagnosis, and how quickly? What percentage of patients progress to later lines of therapy within one year of diagnosis?
• What percentage of MG patients are treated with monotherapy versus combination therapy? What are the most commonly used combinations?
• What are the product-level compliance and persistency rates among drug-treated patients?

Content highlights

Markets covered: United States

Key drugs: Soliris, Vyvgart, Ultomiris, Rystiggo, pyridostigmine

Product description

Treatment Algorithms: Claims Data Analysis provides detailed, quantitative analysis of the treatment journey and brand usage across lines of therapy and overall using real-world, patient-level claims data so that marketers can accurately assess their source of business, benchmark usage against competitors, and quantify areas of opportunity for their marketed or emerging brand.