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In the United States, more than 32 million people suffer from unipolar depression, an indication that consists of major depressive disorder, minor depression, and dysthymia. Unipolar depression is associated with a high rate of drug treatment, which encompasses an extensive range of antidepressant treatments. However, poor patient response rates to treatment result in relatively individualized treatment patterns by both psychiatrists and primary care physicians (PCPs). This content examines psychiatrists’ and PCPs’ intricate treatment paradigms, as well as the motivations behind their prescribing decisions.

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